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	Provedor de dados BJMBR (2) Anais da ABC (AABC) (1) Autor Cai,M. (1) Dai,F. (1) Dong,S.W. (1) JAGANATHAN,SARAVANA KUMAR (1) MANI,MOHAN P. (1) Ren,Q. (1) Ren,W. (1) Su,Z. (1) Sun,D. (1) Sun,T. (1) Wang,J. (1) Xu,J.Z. (1) Yang,T. (1) Zhang,F. (1) Zhang,K. (1) Zhang,Z.H. (1) Mais... Palavra-chave Bone tissue engineering (3) Ayurveda oil (1) BMP-2 (1) Blood compatibility (1) CTLA4 (1) Electrospun scaffold (1) Immunomodulatory (1) Mesenchymal stem cells (1) PELA (1) Polyurethane (1) Scaffold (1) VEGF (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2018 (1) 2015 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última CTLA4 enhances the osteogenic differentiation of allogeneic human mesenchymal stem cells in a model of immune activation BJMBR Dai,F.; Zhang,F.; Sun,D.; Zhang,Z.H.; Dong,S.W.; Xu,J.Z.. Allogeneic mesenchymal stem cells (allo-MSCs) have recently garnered increasing interest for their broad clinical therapy applications. Despite this, many studies have shown that allo-MSCs are associated with a high rate of graft rejection unless immunosuppressive therapy is administered to control allo-immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. Here, we investigated the osteogenic differentiation potency of allo-MSCs in an activated immune system that mimics the in vivo allo-MSC grafting microenvironment and explored the immunomodulatory role of the helper T cell receptor CTLA4 in this process. We found that MSC osteogenic... Tipo: Info:eu-repo/semantics/article Palavras-chave: CTLA4; Mesenchymal stem cells; Immunomodulatory; Bone tissue engineering. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700629 Effects of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) release from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on bone BJMBR Ren,Q.; Cai,M.; Zhang,K.; Ren,W.; Su,Z.; Yang,T.; Sun,T.; Wang,J.. Multiple growth factors can be administered to mimic the natural process of bone healing in bone tissue engineering. We investigated the effects of sequential release of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on bone regeneration. To improve the double emulsion/solvent evaporation technique, VEGF was encapsulated in PELA microcapsules, to which BMP-2 was attached. The scaffold (BMP-2/PELA/VEGF) was then fused to these microcapsules using the dichloromethane vapor method. The bioactivity of the released BMP-2 and VEGF was then quantified in rat mesenchymal stem cells (rMSCs). Immunoblotting analysis showed that BMP-2/PELA/VEG... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bone tissue engineering; BMP-2; VEGF; PELA; Scaffold. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200603 Electrospun novel nanocomposite comprising polyurethane integrated with ayurveda amla oil for bone tissue engineering Anais da ABC (AABC) JAGANATHAN,SARAVANA KUMAR; MANI,MOHAN P.. Abstract Ayurveda oil contains numerous source of biological constituents which plays an important role in reducing the pain relief caused during bone fracture. The aim of the study is to fabricate the polyurethane (PU) scaffold for bone tissue engineering added with ayurveda amla oil using electrospinning technique. Scanning Electron Microscopy (SEM) analysis showed that the fabricated nanocomposites showed reduced fiber diameter (758 ± 185.46 nm) than the pristine PU (890 ± 116.91 nm). Fourier Infrared Analysis (FTIR) revealed the existence of amla oil in the PU matrix by hydrogen bond formation. The contact angle results revealed the decreased wettability (116° ± 1.528) of the prepared nanocomposites compared to the pure PU (100° ± 0.5774). The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polyurethane; Ayurveda oil; Electrospun scaffold; Blood compatibility; Bone tissue engineering. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000101101 Registros recuperados: 3 Primeira ... 1 ... Última

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